Publication: Paneth cells are also target
of the ribotoxic lectin nigrin b
Authors
Jiménez, Pilar ; Gayoso, Manuel José ; Garrosa, Manuel ; Córdoba-Díaz, Damián ; Cabrero, Patricia ; Tejero, Jesús ; Aracil, Mónica ; Girbés, Tomás
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Publisher
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ribosome-inactivating lectins (RILs) are AB type toxins like ricin whose molecular target is the
large rRNA of eukaryotic ribosome. Administration of
lethal doses of the RIL nigrin b isolated from elderberry
(Sambucus nigra L.) bark triggers specific intestinal
derangement. The aim of the present research was to
explore the early effects of a lethal dose of nigrin b (16
mg/kg body weight) on the small intestine using light
and electron microscopy to ascertain intestinal
epithelium changes. 6 h after nigrin administration, the
small intestine crypts began to show signs of damage
with cells appearing at different stages of apoptosis. 16 h
after injection crypts appeared more impaired, including
the derangement of Paneth cells. The novelty of our
results is that the Paneth cells in the small intestine in
addition to stem cells are the early cellular targets for
nigrin b.
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Citation
Histology and Histopathology, vol. 29, nº 8, (2014)
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