Publication: Distribution of T-cell subsets and immunoglobulin-containing cells in
nasal-associated lymphoid tissue (NALT) of chickens
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Date
2000
Authors
Ohshima, K. ; Hiramatsu, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present study demonstrated the
localization of the T-cell subsets (CD4+ and CD8+) and
immunoglobulin (1g)-containing cells (IgA, IgM, and
IgG) in the nasal mucosa and its accessory structures.
These lymphoid structures may be compared with nasalassociated
lymphoid tissue (NALT) of rats and mice. In
the chicken NALT, T-cell subsets were more widely
distributed than Ig-containing cells, especially in large
lymphoid accumulations restricted to the respiratory
mucosa in the nasal cavity and the nasolacrimal duct.
These lymphoid accumulations in the mucosa of the
nasal cavity and nasolacrimal duct consisted of widely
distributed CD8+ cells and deeply aggregated CD4+
cells adjacent to large germinal centers. In these
lymphoid accumulations, IgG-containing cells were
more frequently observed than IgM- and IgA-containing
cells. T-cell subsets, predominantly CD8+ cells were
more widely distributed in the duct epithelium of the
lateral nasal glands than Ig-containing cells. Moreover,
numerous CD8+ cells and a few Ig-containing cells were
found in the chicken salivary glands, especially around
the orifice of their ducts into the oral cavity. Therefore, it
seems likely that the chicken NALT plays an important
part in the upper respiratory tract, with a close
relationship to the paraocular immune system.
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