RhoB in cancer suppression

Publication:
RhoB in cancer suppression

dc.contributor.author	Huang, M.	es
dc.contributor.author	Prendergast, G.C.	es
dc.date.accessioned	2011-06-30T12:02:10Z
dc.date.available	2011-06-30T12:02:10Z
dc.date.issued	2006
dc.description.abstract	RhoB is a mainly endosomal small GTPase that regulates actin organization and vesicle trafficking. Expression of RhoB is elevated rapidly by many stimuli, including growth factors, cytokines, and genotoxic stress. In cancer, RhoB can limit cell proliferation, survival, invasion, and metastasis, and during malignant progression its levels are attenuated commonly. In support of its role as a negative modifier of cancer progression, targeted deletion of RhoB in mice can increase tumor formation initiated by Ras mutation. How RhoB acts to suppress different aspects of cancer pathophysiology has emerged as a question of significant interest.	es
dc.format	application/pdf	es
dc.format.extent	6	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/22614
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Endosome	es
dc.subject	Prenylation	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	RhoB in cancer suppression	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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