Publication: RhoB in cancer suppression
Authors
Huang, M. ; Prendergast, G.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
RhoB is a mainly endosomal small GTPase
that regulates actin organization and vesicle trafficking.
Expression of RhoB is elevated rapidly by many stimuli,
including growth factors, cytokines, and genotoxic
stress. In cancer, RhoB can limit cell proliferation,
survival, invasion, and metastasis, and during malignant
progression its levels are attenuated commonly. In
support of its role as a negative modifier of cancer
progression, targeted deletion of RhoB in mice can
increase tumor formation initiated by Ras mutation. How
RhoB acts to suppress different aspects of cancer
pathophysiology has emerged as a question of
significant interest.
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Citation
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