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Mandibular bone alterations of ovariectomized rats under vitamin D insufficiency

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dc.contributor.authorSaid, Faikaes
dc.contributor.authorGhoul-Mazgar, Soniaes
dc.contributor.authorRuhin, Blandine
dc.contributor.authorAbdellaoui, Mohieddine
dc.contributor.authorChlaghmia, Faycel
dc.contributor.authorSafta, Sihem
dc.contributor.authorGuezguez, Leila
dc.contributor.authorSaidane-Mosbahi, Dalila
dc.contributor.authorKhemiss, Fathia
dc.date.accessioned2013-01-18T13:29:22Z
dc.date.available2013-01-18T13:29:22Z
dc.date.issued2008
dc.description.abstractExperimental osteoporosis was studied in mandible bone by means of ovariectomy and vitamin D insufficiency. METHODS: 42 female Wistar rats were divided into the following four groups: (1) ovariectomized rats maintained in 12h day-night light conditions (ov-l), (2) ovariectomized rats maintained in 24h dark light conditions (ov-ob), (3) sham-operated rats maintained in 12h day-night light conditions (ch-l) and (4) sham-operated rats maintained in 24 h dark conditions (ch-ob). 12 weeks later the animals were sacrificed, the mandibles were excised, cleaned and weighed, the right side of the mandibles were histologically examined and the left side of the mandibles were prepared for mineral phase analysis by X-ray diffraction. Immunohistochemical analysis was performed to detect apoptotic cells by anti-PARP p85 antibody. RESULTS: In group 2, the weight of mandibles significantly decreased. Chondroid areas were observed in ovariectomized groups and polarized light observation validated the collagen distribution disturbance in these groups (groups 1 and 2). Apoptotic osteoblasts were localized in groups 1, 2 and 4. They were numerous in group 2. The mineral phase analysis did not find differences between the groups. CONCLUSION: This study validates a new model of osteoporotic animal associating estrogens deficiency and vitamin D insufficiency where matrix synthesis and osteoblast biology are altered, but not biomineralization.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29683
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOvariectomyes
dc.subjectMandiblees
dc.subject.other616.3 - Patología del aparato digestivo. Odontologíaes
dc.titleMandibular bone alterations of ovariectomized rats under vitamin D insufficiencyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23, nº4 (2008)