Publication:
Sonoelastography for the Assessment of Muscle Changes in Amyotrophic Lateral Sclerosis: Results of a Pilot Study

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Date
2018
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Authors
Martínez Payá, Jacinto Javier ; Baño Aledo, María Elena del ; Ríos Díaz, José ; Fornés Ferrer, Victoria ; Vázquez Costa, Juan F.
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Publisher
Elsevier
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Fisioterapia
DOI
https://doi.org/10.1016/j.ultrasmedbio.2018.08.009
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Description
©<2018>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in [Ultrasound in Medicine & Biology]. To access the final edited and published work see [https://doi.org/10.1016/j.ultrasmedbio.2018.08.009]
Abstract
The purpose of this study was to assess the sonoelastographic features of four different muscles in patients with amyotrophic lateral sclerosis compared with healthy controls and to evaluate the relationship of these features to muscle strength and other ultrasonographic variables. Fourteen patients with amyotrophic lateral sclerosis and 20 controls were examined using strain sonoelastography scanning. The RGB channel fraction ratio was analyzed with ImageJ software (Version 1.48). Two main sonoelastographic patterns could be distinguished in the controls: a clear predominance of the blue channel (hard areas) and a more heterogeneous pattern with predominance of the green channel (intermediate stiffness). These patterns were also observed in patients, although a higher green channel score was observed in mildly impaired muscles, whereas a higher blue channel score was observed in the most severely impaired muscle. Sonoelastography may be a good complementary biomarker in the detection and monitoring of muscle changes in amyotrophic lateral sclerosis.
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Amyotrophic lateral sclerosis , Atrophy , Fasciculations , Peripheral nervous system diseases , Bio-markers , Elasticity imaging techniques , Sonoelastography , Motor neuron disease , Neuro muscular diseases , Ultrasonography
Citation
Ultrasound in Medicine & Biology. Volume 44, Issue 12, December 2018, Pages 2540-2547
URI
http://hdl.handle.net/10201/138291
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