Publication: Breast carcinoma vascularity, A comparison of manual microvessel count and Chalkley count
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Date
2009
Authors
Dhakal, Hari Prasad ; Bassarova, A.V. ; Naume, Bjørn ; Synnestvedt, Marit ; Borgen, Elin ; Kaaresen, Rolf ; Schlichting, Ellen ; Wiedswang, Gro ; Giercksky, Karl- Erik ; Nesland, Jahn M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
. Manual counting of microvessels as
intratumoral microvessel density (MVD) and Chalkley
counting have been used in several studies to assess the
prognostic impact of vascularity in invasive breast
carcinomas. In our present study, the aim was to evaluate
the prognostic value of angiogenesis in invasive breast
carcinoma assessed by MVD and Chalkley techniques in
the same series of patients. A total of 498 breast
carcinoma patients with median follow up time 85
months were evaluated. The tumour vascularity was
quantified by both manual microvessel count (MVD)
and Chalkley count in CD34 stained breast carcinoma
slides by a single investigator blinded to clinical
information. Other relevant clinicopathological
parameters were noted, including breast cancer related
death and both loco-regional and systemic relapse. The
patients were stratified by converting MVD and
Chalkley counts to categorical variables to assess
prognostic impact, and results were compared. High
vascular grades using MVD count did not demonstrate
any prognostic significance for breast cancer specific
survival (BCSS) or distant disease free survival (DDFS)
either in whole patient group (BCSS, p=0.517, DDFS,
p=0.301) or in non-treated node negative patients
(p>0.05). Chalkley count showed prognostic
significance for both DDFS and BCSS in whole patient
group (p<0.001) and also in untreated node negative
patient group (p<0.05). In multivariate analysis,
Chalkley count, but not MVD, retained the prognostic
value for BCSS (p=0.007) and DDFS (p=0.014). The
Chalkley count for assessing angiogenesis in invasive
breast carcinomas demonstrated prognostic value. The
Chalkley method appears to be the better method in
estimating the prognostic impact of vascularity in
invasive breast carcinomas.
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