Publication:
The role of the CXCR4/CXCL12 axis and its clinical implications in gastric cancer

Simple item page
dc.contributor.authorLee, Hyo Jin
dc.contributor.authorJo, Deog Yeon
dc.date.accessioned2017-09-08T18:16:09Z
dc.date.available2017-09-08T18:16:09Z
dc.date.issued2012
dc.description.abstractGastric cancer is the second leading cause of cancer deaths worldwide. Despite the extensive body of research on gastric cancer, the prognosis of patients with advanced gastric cancer remains poor, and therapy for advanced gastric cancer relies largely on cytotoxic chemotherapy. Therefore, identifying the distinct molecular pathways underlying disease progression and treatment resistance may lead to novel therapeutic approaches, as well as improve the quality of life and survival of patients. The chemokine CXCL12 and its receptor CXCR4 are now known to play an important role in cancer development and progression. Here, we review the expression and function of CXCR4 and CXCL12, as well as their clinical relevance in gastric cancer. We also cover the current molecular mechanism, specifically the cell-signaling pathway, by which gastric cancer progresses through the CXCR4/CXCL12 axis, and discuss the potential of that axis as a therapeutic target in the treatment of gastric canceres
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 9 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54120
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectGastric canceres
dc.subjectChemokinees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe role of the CXCR4/CXCL12 axis and its clinical implications in gastric canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Lee-27-1155-1161-2012.pdf
Size:
1.95 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.27, nº 9 (2012)