Publication:
Clonal relationship of relapsing lymphoid neoplasms

Simple item page
dc.contributor.authorObermann, E.C.
dc.contributor.authorDirnhofer, S.
dc.contributor.authorTzankov, A.
dc.date.accessioned2017-09-07T18:12:56Z
dc.date.available2017-09-07T18:12:56Z
dc.date.issued2012
dc.description.abstractLymphomas encompass a broad spectrum of neoplasias. Traditionally it has been assumed that recurrent neoplasia, especially lymphoma, represents a relapse of the original clone. However, this concept has been challenged. Here we present an overview of novel perceptions regarding the clonal relationship of relapsing lymphoid neoplasms, i.e. precursor cell acute lymphoblastic lymphoma/leukemia (ALL), so called non-Hodgkin lymphomas (NHL) and classical Hodgkin lymphoma (cHL) and discuss the potential implications of these findings. In ALL, approximately 10% of “relapses” were found to be clonally unrelated to the original disease. In NHL, small series and case reports showed the occurrence of meta- or synchronous lymphoid malignancies, which were of different clonal origin. In cHL, there is evidence that both early and late “relapses” may constitute to a certain proportion a novel neoplasm of different clonal origin too. These findings warrant further investigations in order to verify and strengthen the existing data and might have important clinical implications because novel clonally unrelated lymphomas imitating relapses could possibly be treatable with less aggressive regimens compared to true recurrenceses
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 8 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54083
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectClonalityes
dc.subjectRecurrencees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleClonal relationship of relapsing lymphoid neoplasmses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Obermann-27-1013-1020-2012.pdf
Size:
3.77 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.27, nº 8 (2012)