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Dysregulated stemness-related genes in gynecological malignancies

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dc.contributor.authorMak, Victor C.Y.
dc.contributor.authorSiu, Michelle K.Y.
dc.contributor.authorWong, Oscar G.W.
dc.contributor.authorChan, Karen K.L.
dc.contributor.authorNgan, Hextan Y.S.
dc.contributor.authorCheung, Annie N.Y.
dc.date.accessioned2017-09-08T17:44:32Z
dc.date.available2017-09-08T17:44:32Z
dc.date.issued2012
dc.description.abstractIn recent years, much attention has been paid to the concept of cancer stem cells (CSC) and self-renewal related pathways in cancer biology. This review outlines the dysregulated stemness-related genes or transcription factors in gynecological cancers. Hedgehog (Hh) and Notch signaling are important pathways in tissue pattern programming and cell fate determination during embryonic development. Hyperactivation of these two pathways was frequently observed in gynecological malignancies such as ovarian, endometrial and cervical cancers. In contrast, the expression profiles of pluripotency-regulating core transcriptional circuitry: Nanog, Oct4 and Sox2 appear heterogeneous. Among these transcription factors, overexpression of Nanog was found to exert a prominent effect in gynecological tumorigenesis, while dysregulations of Oct4 and Sox2 may vary in a context dependent manner. On the other hand, the isolation of putative CSC illustrates a hierarchy model of tumor heterogeneity, in which only a subset of cells among biologically distinct populations can initiate tumor growth. Re-activation of these pluripotent transcription factors (Nanog, Oct4 and/or Sox2) in association with distinct tumorigenic properties could be found in clones isolated from gynecological tumors using various approaches. Recent understanding on the roles of Hh and Notch signaling in enhancing CSC survival may help to better understand the mechanism of carcinogenesis and identify new pharmaceutical targets for gynecological malignancieses
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 9 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54117
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCancer stem cellses
dc.subjectGynecological cancerses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetriciaes
dc.titleDysregulated stemness-related genes in gynecological malignancieses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 9 (2012)