Publication: The controversial nuclear matrix: a balanced point of view
Authors
Martelli, A.M. ; Falcieri, E. ; Zweyer, M. ; Bortul, R. ; Tabellini, G. ; Cappellini, A. ; Cocco, L.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The nuclear matrix is defined as the residual
framework after the removal of the nuclear envelope,
chromatin, and soluble components by sequential
extractions. According to several investigators the
nuclear matrix provides the structural basis for
intranuclear order. However, the existence itself and the
nature of this structure is still uncertain. Although the
techniques used for the visualization of the nuclear
matrix have improved over the years, it is still unclear to
what extent the isolated nuclear matrix corresponds to an
in vivo existing structure. Therefore, considerable
scepticism continues to surround the nuclear matrix
fraction as an accurate representation of the situation in
living cells. Here, we summarize the experimental
evidence in favor of, or against, the presence of a diffuse
nucleoskeleton as a facilitating organizational
nonchromatin structure of the nucleus.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.