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Cavernomas of the human brainstem: 3-dimensional reconstruction from histological slides using computerized techniques

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dc.contributor.authorToralba, Simon
dc.contributor.authorLandemore, Gérard
dc.contributor.authorCoquemont, Maëlle
dc.contributor.authorPlancoulaine, Benoit
dc.contributor.authorChapon, Françoise
dc.date.accessioned2019-07-22T07:22:57Z
dc.date.available2019-07-22T07:22:57Z
dc.date.issued2014
dc.description.abstractCerebral cavernous malformations (CCMs) are described as vascular lesions consisting of endothelial-lined dilated vessels embedded in a connective tissue sheath without intervening parenchyma between them. Their anatomical connections with the normal blood vessels are still enigmatic and the fine three-dimensional (3-D) organization of these vascular lesions remains to be established. Two stacks of serial histological slices, obtained from two brainstem CCM lesions (from the necropsy of a CCM2 male patient), were stained using Masson’s trichrome method and then digitized. Stacks of regions of interest underwent quasi-automatic processing: 1) propagative registering using blockmatching algorithms and Brain Visa programs; 2) 3-D segmentation using Aphelion; 3) display with Anatomist or ImageVis3D. These first histological 3-D reconstructions show the external limits of the caverns defined as the external limit of their collagen sheath. These pictures not only reveal the gross spatial organization of the lesions, but due to their high resolution (4 µm) and with the help of simple anaglyphic 3-D rendering, they also allow the visualization of connections between caverns and very small blood vessels.es
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dc.identifier.citationHistology and Histopathology, vol. 29, nº 8, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/73961
dc.languageenges
dc.languagedeues
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCavernomaes
dc.subject3-D reconstructiones
dc.subjectVascular diseasees
dc.subjectBrain sectionses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleCavernomas of the human brainstem: 3-dimensional reconstruction from histological slides using computerized techniqueses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 8 (2014)