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Immunohistochemical evaluation of tissues following bone implant extraction from upper and lower limb

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dc.contributor.authorBielniková Kryštofová, Hana
dc.contributor.authorMotyka, Oldřich
dc.contributor.authorŽidlík, Vladimír
dc.contributor.authorŽiak, Dušan
dc.contributor.authorSzotkovská, Iveta
dc.contributor.authorŠkarda, Jozef
dc.contributor.authorPometlová, Jana
dc.contributor.authorPleva, Leopold
dc.contributor.authorHavlíček, Miroslav
dc.contributor.authorČabanová, Kristina
dc.date.accessioned2023-09-28T09:02:52Z
dc.date.available2023-09-28T09:02:52Z
dc.date.issued2023
dc.description.abstractFractured bones can regenerate and restore their biological and mechanical properties to the state prior to the damage. In some cases, however, the treatment of fractures requires the use of supportive implants. For bone healing, three processes are essential: the inflammatory phase, the repair phase and the remodelling phase. A proper course of the first - inflammatory - stage is important to ensure a successful fracture healing process. In our study, we evaluated tissue samples immunohistochemically from the area surrounding the fractures of upper and lower limbs (bone tissue, soft tissue, and the implant-adhering tissue) for markers: CD11b, CD15, CD34, CD44, CD68, Cathepsin K, and TRAcP that are linked to the aforementioned phases. In soft tissue, higher expressions of CD68, CD34, CD15 and CD11b markers were observed than in other locations. TRAcP and Cathepsin K markers were more expressed in the bone tissue, while pigmentation, necrosis and calcification were more observed in the implant-adhering tissue. Since even the implant materials commonly perceived as inert elicit the observed inflammatory responses, new surface treatments and materials need to be developed.es
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dc.format.extent9es
dc.identifier.citationHistology and Histopathology, Vol.38, nº10, (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-606
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/134347
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFracturees
dc.subjectInflammationes
dc.subjectHealinges
dc.subjectForeign body reactiones
dc.subjectPigmentationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleImmunohistochemical evaluation of tissues following bone implant extraction from upper and lower limbes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38,nº10 (2023)