Publication: Immunohistochemical evaluation of tissues following bone implant extraction from upper and lower limb
Authors
Bielniková Kryštofová, Hana ; Motyka, Oldřich ; Židlík, Vladimír ; Žiak, Dušan ; Szotkovská, Iveta ; Škarda, Jozef ; Pometlová, Jana ; Pleva, Leopold ; Havlíček, Miroslav ; Čabanová, Kristina
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-18-606
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info:eu-repo/semantics/article
Description
Abstract
Fractured bones can regenerate and restore
their biological and mechanical properties to the state
prior to the damage. In some cases, however, the
treatment of fractures requires the use of supportive
implants. For bone healing, three processes are essential:
the inflammatory phase, the repair phase and the
remodelling phase. A proper course of the first -
inflammatory - stage is important to ensure a successful
fracture healing process. In our study, we evaluated
tissue samples immunohistochemically from the area
surrounding the fractures of upper and lower limbs (bone
tissue, soft tissue, and the implant-adhering tissue) for
markers: CD11b, CD15, CD34, CD44, CD68, Cathepsin
K, and TRAcP that are linked to the aforementioned
phases. In soft tissue, higher expressions of CD68,
CD34, CD15 and CD11b markers were observed than in
other locations. TRAcP and Cathepsin K markers were
more expressed in the bone tissue, while pigmentation,
necrosis and calcification were more observed in the
implant-adhering tissue. Since even the implant
materials commonly perceived as inert elicit the
observed inflammatory responses, new surface
treatments and materials need to be developed.
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Citation
Histology and Histopathology, Vol.38, nº10, (2023)
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