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State-of-the-art review on the correlations between pathological and magnetic resonance features of cirrhotic nodules

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dc.contributor.authorRenzulli, Matteo
dc.contributor.authorBraccischi, Lorenzo
dc.contributor.authorD’Errico, Antonietta
dc.contributor.authorPecorelli, Anna
dc.contributor.authorBrandi, Nicolò
dc.contributor.authorGolfieri, Rita
dc.contributor.authorAlbertini, Elisa
dc.contributor.authorVasuri, Francesco
dc.date.accessioned2023-03-08T08:50:46Z
dc.date.available2023-03-08T08:50:46Z
dc.date.issued2022
dc.description.abstractHepatocellular carcinoma (HCC) has become the second greatest cause of cancer-related mortality worldwide and the newest advancements in liver imaging have improved the diagnosis of both overt malignancies and premalignant lesions, such as cirrhotic or dysplastic nodules, which is crucial to improve overall patient survival rate and to choose the best treatment options. The role of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) has grown in the last 20 years. In particular, the introduction of hepatospecific contrast agents has strongly increased the definition of precursor nodules and detection of highgrade dysplastic nodules and early HCCs. Nevertheless, the diagnosis of liver tumours in cirrhotic patients sometimes remains challenging for radiologists, thus, in doubtful cases, biopsy and histological analysis become critical in clinical practice. This current review briefly summarizes the history of imaging and histology for HCC, covering the newest techniques and their limits. Then, the article discusses the links between radiological and pathological characteristics of liver lesions in cirrhotic patients, by describing the multistep process of hepato carcinogenesis. Explaining the evolution of pathologic change from cirrhotic nodules to malignancy, the list of analyzed lesions provides regenerative nodules, lowgrade and high-grade dysplastic nodules, small HCC and progressed HCC, including common subtypes (steatohepatitic HCC, scirrhous HCC, macrotrabecular massive HCC) and more rare forms (clear cell HCC, chromophobe HCC, neutrophil-rich HCC, lymphocyterich HCC, fibrolamellar HCC). The last chapter covers the importance of the new integrated morphologicalmolecular classification and its association with radiological featureses
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationHistology and Histopathology Vol. 37, nÂş12 (2022)
dc.identifier.doihttps://doi.org/10.14670/HH-18-487
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129145
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLiveres
dc.subjectLiver imaginges
dc.subjectMagnetic resonance imaginges
dc.subjectHepatocellular carcinomaes
dc.subjectCirrhosises
dc.subjectImmunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleState-of-the-art review on the correlations between pathological and magnetic resonance features of cirrhotic noduleses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.37,nÂş12 (2022)