Publication: State-of-the-art review on the correlations between pathological and magnetic resonance features of cirrhotic nodules
Authors
Renzulli, Matteo ; Braccischi, Lorenzo ; D’Errico, Antonietta ; Pecorelli, Anna ; Brandi, Nicolò ; Golfieri, Rita ; Albertini, Elisa ; Vasuri, Francesco
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-487
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info:eu-repo/semantics/article
Description
Abstract
Hepatocellular carcinoma (HCC) has become
the second greatest cause of cancer-related mortality
worldwide and the newest advancements in liver
imaging have improved the diagnosis of both overt
malignancies and premalignant lesions, such as cirrhotic
or dysplastic nodules, which is crucial to improve
overall patient survival rate and to choose the best
treatment options. The role of Computed Tomography
(CT) and Magnetic Resonance Imaging (MRI) has
grown in the last 20 years. In particular, the introduction
of hepatospecific contrast agents has strongly increased
the definition of precursor nodules and detection of highgrade dysplastic nodules and early HCCs. Nevertheless,
the diagnosis of liver tumours in cirrhotic patients
sometimes remains challenging for radiologists, thus, in
doubtful cases, biopsy and histological analysis become
critical in clinical practice.
This current review briefly summarizes the history
of imaging and histology for HCC, covering the newest
techniques and their limits. Then, the article discusses
the links between radiological and pathological
characteristics of liver lesions in cirrhotic patients, by
describing the multistep process of hepato
carcinogenesis. Explaining the evolution of pathologic
change from cirrhotic nodules to malignancy, the list of
analyzed lesions provides regenerative nodules, lowgrade and high-grade dysplastic nodules, small HCC and
progressed HCC, including common subtypes
(steatohepatitic HCC, scirrhous HCC, macrotrabecular
massive HCC) and more rare forms (clear cell HCC,
chromophobe HCC, neutrophil-rich HCC, lymphocyterich HCC, fibrolamellar HCC). The last chapter covers
the importance of the new integrated morphologicalmolecular classification and its association with
radiological features
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Citation
Histology and Histopathology Vol. 37, nÂş12 (2022)
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