Immunopathology of autoimmune gastritis: Lessons from mouse models

Alderuccio, F.; Toh, B. H.

Publication:
Immunopathology of autoimmune gastritis: Lessons from mouse models

dc.contributor.author	Alderuccio, F.
dc.contributor.author	Toh, B. H.
dc.date.accessioned	2020-07-23T12:44:38Z
dc.date.available	2020-07-23T12:44:38Z
dc.date.issued	2000
dc.description.abstract	Autoimmune gastritis in humans is a chronic inflammatory disease of the stomach accompanied by specific destruction of gastric parietal and zymogenic cells resulting in pernicious anemia. Human gastritis can be accurately reproduced in mice and is characterised by autoantibodies to the a- and B-subunits of the gastric H/K ATPase (the enzyme responsible for gastric acid secretion) and cellular destruction of parietal and zymogenic cells within the gastric gland. Studies with these mouse models have given us our current concepts of the immunopathogenesis of the gastritis. Mouse models have shown that a T cell response is generated to the a- and B-subunits of the H/K ATPase and that an immune response to the B-subunit seems to be required for disease initiation. Using these models, we have defined key events associated with a damaging autoimmune response to the gastric H/K ATPase. The mechanisms associated with the cellular destruction associated with autoimmune gastritis are not know, but may involve signaling through death inducing pathways such as the Fas/FasL and TNF/TNFR pathways. This knowledge should permit us to develop strategies to prevent and treat the gastritis.	es
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.citation	Histology and Histopathology, Vol. 15, n.º 3 (2000)
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/95170
dc.language	eng	es
dc.publisher	F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Autoimmune gastritis	es
dc.subject	Autoimmunity	es
dc.subject	Transgenic mice	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología	es
dc.title	Immunopathology of autoimmune gastritis: Lessons from mouse models	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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