Publication: Immunopathology of autoimmune gastritis: Lessons from mouse models
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Date
2000
Authors
Alderuccio, F. ; Toh, B. H.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Autoimmune gastritis in humans is a chronic
inflammatory disease of the stomach accompanied by
specific destruction of gastric parietal and zymogenic
cells resulting in pernicious anemia. Human gastritis can
be accurately reproduced in mice and is characterised by
autoantibodies to the a- and B-subunits of the gastric
H/K ATPase (the enzyme responsible for gastric acid
secretion) and cellular destruction of parietal and
zymogenic cells within the gastric gland. Studies with
these mouse models have given us our current concepts
of the immunopathogenesis of the gastritis. Mouse
models have shown that a T cell response is generated to
the a- and B-subunits of the H/K ATPase and that an
immune response to the B-subunit seems to be required
for disease initiation. Using these models, we have
defined key events associated with a damaging
autoimmune response to the gastric H/K ATPase. The
mechanisms associated with the cellular destruction
associated with autoimmune gastritis are not know, but
may involve signaling through death inducing pathways
such as the Fas/FasL and TNF/TNFR pathways. This
knowledge should permit us to develop strategies to
prevent and treat the gastritis.
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Citation
Histology and Histopathology, Vol. 15, n.º 3 (2000)
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