Publication:
Trichloroethylene exposure elicits damage in epididymal epithelium and spermatozoa in mice

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dc.contributor.authorKan, F.W.K.es
dc.contributor.authorForkert, P.G.es
dc.contributor.authorWade, M.G.
dc.date.accessioned2012-05-21T12:10:52Z
dc.date.available2012-05-21T12:10:52Z
dc.date.issued2012-05-21
dc.date.issued2007
dc.description.abstractWe have investigated the toxic effects of trichloroethylene (TCE) on the epididymis and epididymal sperm in mice. Mice were exposed to TCE (1000 ppm) by inhalation for 6 h/day for 5 days/week for 1 to 4 weeks. Segments of the epididymis (caput, corpus and cauda) were examined by light and electron microscopy. At the light microscopic level, degeneration and sloughing of epithelial cells were evident as early as 1 week after TCE exposure, and were most pronounced after 4 weeks. Such epithelial damage was observed in the caput, corpus and cauda regions of the epididymis. Ultrastructural observations revealed vesiculation in the cytoplasm, disintegration of basolateral cell membranes, and sloughing of epithelial cells. Sperm were found in situ in the cytoplasm of degenerated epididymal cells. Additionally, a large number of sperm in the epididymal lumen exhibited abnormalities including malformation of head and tail components. Our results demonstrated that exposure to TCE by inhalation causes damage to the epididymal epithelium and sperm.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27631
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectTrichloroethylenees
dc.subjectSpermes
dc.subject.other615 - Farmacología. Terapéutica. Toxicología. Radiologíaes
dc.titleTrichloroethylene exposure elicits damage in epididymal epithelium and spermatozoa in micees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 9 (2007)