Publication: Trichloroethylene exposure elicits damage in epididymal epithelium and spermatozoa in mice
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Date
2012-05-21 , 2007
Authors
Kan, F.W.K. ; Forkert, P.G. ; Wade, M.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have investigated the toxic effects of
trichloroethylene (TCE) on the epididymis and
epididymal sperm in mice. Mice were exposed to TCE
(1000 ppm) by inhalation for 6 h/day for 5 days/week for
1 to 4 weeks. Segments of the epididymis (caput, corpus
and cauda) were examined by light and electron
microscopy. At the light microscopic level, degeneration
and sloughing of epithelial cells were evident as early as
1 week after TCE exposure, and were most pronounced
after 4 weeks. Such epithelial damage was observed in
the caput, corpus and cauda regions of the epididymis.
Ultrastructural observations revealed vesiculation in the
cytoplasm, disintegration of basolateral cell membranes,
and sloughing of epithelial cells. Sperm were found in
situ in the cytoplasm of degenerated epididymal cells.
Additionally, a large number of sperm in the epididymal
lumen exhibited abnormalities including malformation
of head and tail components. Our results demonstrated
that exposure to TCE by inhalation causes damage to the
epididymal epithelium and sperm.
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