Publication: Temporomandibular joint disc; a proposed histopathological degeneration grading score system
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Date
2010
Authors
Leonardi, Rosalia ; Rusu, Mugurel Constantin ; Loreto, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. Aims: The purpose of this study was to draw
up a TMJ disc histopathological score that is a semiquantitative
transcription of the entire spectrum of TMJ
disc degenerative diseases related to changes in disc
tissue, and then validate the proposed grading, in order
to contribute to a standardized histopathological
diagnosis. Methods: Sections from sixty two
temporomandibular joint disc specimens affected by
tissue degenerative changes and stained with
Hematoxylin & Eosin (H&E) were collected from
among those found in the archives of the Department of
Dentistry at Catania University. Specimens, included
anterior, intermediate and posterior disc bands. Based on
a literature search regarding the most frequent
histopathological changes detected in TMJ disc tissue a
grading score was designed. This score takes into
account pathological disc tissue transformation i.e.
collagen bundles, non-specific degenerative changes and
the presence of blood vessels. This grading system
results in a score ranging from 0 up to 8 for heavily
degenerated disc tissue. Two observers performed the
assessment of the TMJ disc H&E stained sections. Each
specimen was scored twice by each observer after a
minimum interval of 1 week. Results: The average TMJ
disc degeneration score of the TMJ disc sample was
3.89±1.37. There was an almost perfect agreement,
between the two observers, and degeneration scores
from the two observers were highly correlated.
Conclusions: The introduction of this validated
degeneration score system may be of major importance
for future research and collaboration between different
centers in order to improve knowledge in TMJ disc
histopathology.
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