Browsing by Subject "Degeneration"
Now showing 1 - 9 of 9
Results Per Page
Sort Options
- PublicationOpen AccessBiopolítica, nazismo, franquismo. Una aproximación comparativa(Universidad Nacional de Educación a Distancia (UNED), 2011-12-01) Cayuela Sánchez, Salvador; FilosofíaSobre la base de una determinada forma de entender el concepto de biopolítica y sus elementos definitorios, hemos tratado aquí de analizar las características fundamentales de las formas de biopolítica orquestadas por los regímenes nazi y franquista. Dicha caracterización nos ha permitido elaborar, en función de una serie de elementos presentes en ambas biopolíticas, una visión comparativa encargada de mostrar tanto las similitudes como las diferencias entre una y otra, aportando así tanto una nueva conceptualización de los regímenes fascistas, como ciertos elementos ignorados hasta ahora en el debate sobre la naturaleza del franquismo.
- PublicationOpen AccessDegenerative changes of the interface membrane as a possible reason for prosthesis loosening(Murcia : F. Hernández, 2008) Krohmer, Gerhard; Koleganova, Nadezda; Hadjicostas, Panayiotis T.; Fink, Bernd; Berger, I.Objective: The aim of the present study was to perform a comparative evaluation of septic and aseptic interface membranes, assessing histological features, inflammatory infiltrate, and expression of inflammatory cytokines. Methods: Septic and aseptic interface membranes from 102 patients were examined by histology, histochemistry, and immunohistochemistry (tissue arrays). The cell subpopulations were characterized by quantification of CD3, CD4, CD8, CD20, and CD163 positive cells. Additionally, a semiquantitative evaluation of inflammatory cytokines (TNFa, TGF-ß1, IL-1, IL-6, CRP, MMP-1, MMP-6) was performed to complete the analysis of inflammatory infiltrates. Results: The histological analysis revealed three different types of aseptic interface membranes: wear particle, degenerative, and mixed type. The expression of inflammatory molecules did not differ between septic and wear particle interface membranes. Significantly lower expression of cytokines, MMPs and CRP was observed, however, in degenerative interface membranes compared to other types. No expression of TNFa was observed in the degenerative interface membranes. Over 88% of patients with degenerative interface membranes had had a clinical record of osteoarthritis. Conclusion: Aseptic interface membranes were represented by wear particle, degenerative and mixed type. The expression of inflammatory factors in wear particle type is similar to this in septic membranes and can contribute to the bone destruction and prosthesis loosening. These factors seem not to play a major role in the degenerative membranes.
- PublicationOpen AccessDegenerative physiochemical events in the pathological intervertebral disc(Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2022) Lama, Polly; Tewari, Jerina; Adams, Michael A; Le Maitre, Christine. Low back pain is one of the commonest musculoskeletal complaints that affects individuals of all ages and is a leading contributor towards work loss worldwide. The range of current treatment modalities involving surgeries, injectable agents, and medications is promising but cannot address the reasons behind the occurrence of pain in patients with degenerative disc pathologies. One possible factor for the limited success is the lack of evidence behind the identification of early, intermediate, and late stages of painful changes methodologically in a vast group of populations and the manifestation of the diseases in terms of increased physical activity, hereditary patterns, and various risk factors. However, despite these challenges, steady progress has been achieved in understanding the parameters in abnormally loaded progressively degenerating discs and these features have been elucidated at a physical, biochemical, and cellular level. These recent findings can likely lead to the development of therapeutic interventions that will identify and retard tissue damage, decrease pain, and improve the quality of life in these patients. Therefore, the main aim of this review is to integrate recent updates in intervertebral disc degeneration research for the development of evidence-based screening protocols and more targeted interventions in the management of low back pain.
- PublicationOpen AccessFine structural changes in the rat brain after local injections of gliotoxin, alpha-aminoadipic acid(Murcia : F. Hernández, 1986) Takada, M.; Hattori, T.Tosic effect3 of locally injected gliotoxin, l_- alpha-aminoadipic acid, were examined in the adult rat brain at the fine structural level. Astrocytes were the only cell type in the corpus striatum that showed clear structural degeneration 1 to 3 days after the treatment. With a 7 da) \ur\ival period, two major structural changes were detectable, including tremendous in\,asion of astrocytes and their processes, and an appearance of a large number of microglia around injection sites. Both the stereospecificity and cellular specificity were firmly established on the toxic effects of this chemical.
- PublicationOpen AccessFurther characterization of spontaneous arthritic changes in murine squamo-mandibular joint: histopathological aspects(Murcia : F. Hernández, 1986) Livne, E.; Silbermann, M.The appearance of age-related ulcerative changes in the mouse mandibular condyle were evaluated by light and electron microscopy examinations. Fibrillations appeared along the articular surface and in deeper tissue regions, as early as at six months of age. Such changes were characterized by a marked loss of the tissue's cellularity and by a marked reduction in matrix metachromasia and safranin-0 staining. These microscopical changes were accompanied by a reduced reactivity for both ruthenium red and colloidal iron binding, as noted ultrastructurally. At the same time, increasing numbers of erythrocytes appeared to be adhered to the surface irregularities and were also found in deeper regions within the articular lesions. Using morphological criteria, it became apparent that the degenerative changes of aging articular cartilage started at the more superficial regions of the tissue and only thereafter proceeded toward the chondro-osseous junction. Also, with the advancement of age, the degenerative changes became more severe
- PublicationOpen AccessNeuroectodermal grafting: A new tool for the study of neurodegenerative diseases(Murcia : F. Hernández, 1996) Isenmann, S.; Brandner, S.; Aguzzi, A.Transgenic and knockout mice have contributed much to our current understanding of the role played by single genes during development and in pathological processes of the CNS, such as neurodegeneration. However, embryonic lethality resulting from the disruption of important genes has often hindered the interpretation of such experiments. Grafting of immature cells from genetically modified organisms into healthy recipients promises to efficiently bypass this problem. We have used neural transplantation techniques which allow us to keep CNS tissue of knockout and transgenic mice viable for a prolonged period of time in the brain or in the kidney capsule of healthy recipients. We have characterized biological parameters such as growth, proliferation and differentiation and also the formation of an intact blood-brain barrier (BBB) after grafting of wild-type telencephalic anlage in this system. We have also employed this technique to study the longterm properties of neuroepithelial tissue derived from knockout mice. The results of our studies are discussed in the context of neurodegenerative diseases.
- PublicationOpen AccessSymmetry of the definition of degeneration in triangulated categories(2019) Saorín Castaño, Manuel; Zimmermann, A.; Matemáticas
- PublicationOpen AccessTemporomandibular joint disc; a proposed histopathological degeneration grading score system(Murcia : F. Hernández, 2010) Leonardi, Rosalia; Rusu, Mugurel Constantin; Loreto, C.Summary. Aims: The purpose of this study was to draw up a TMJ disc histopathological score that is a semiquantitative transcription of the entire spectrum of TMJ disc degenerative diseases related to changes in disc tissue, and then validate the proposed grading, in order to contribute to a standardized histopathological diagnosis. Methods: Sections from sixty two temporomandibular joint disc specimens affected by tissue degenerative changes and stained with Hematoxylin & Eosin (H&E) were collected from among those found in the archives of the Department of Dentistry at Catania University. Specimens, included anterior, intermediate and posterior disc bands. Based on a literature search regarding the most frequent histopathological changes detected in TMJ disc tissue a grading score was designed. This score takes into account pathological disc tissue transformation i.e. collagen bundles, non-specific degenerative changes and the presence of blood vessels. This grading system results in a score ranging from 0 up to 8 for heavily degenerated disc tissue. Two observers performed the assessment of the TMJ disc H&E stained sections. Each specimen was scored twice by each observer after a minimum interval of 1 week. Results: The average TMJ disc degeneration score of the TMJ disc sample was 3.89±1.37. There was an almost perfect agreement, between the two observers, and degeneration scores from the two observers were highly correlated. Conclusions: The introduction of this validated degeneration score system may be of major importance for future research and collaboration between different centers in order to improve knowledge in TMJ disc histopathology.
- PublicationOpen AccessTWEAK/Fn14 signaling: a promising target in intervertebral disc degeneration(Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Liu, Yu-Ping; Yuan, Chong-Ming; Zhang, Shuai-Gong; Hao, Qing-Hai; Wang, Ming-Ming; Zhang, Zhong; Meng, Qian; Li, Ming; Hao, Yue-Dong