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Markers of senescence are often associated with neuronal differentiation in the developing sensory systems

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dc.contributor.authorMera Rodríguez, José Antonio
dc.contributor.authorÁlvarez Hernán, Guadalupe
dc.contributor.authorGañán, Yolanda
dc.contributor.authorSolana Fajardo, Jorge
dc.contributor.authorMartín Partido, Gervasio
dc.contributor.authorRodríguez León, Joaquín
dc.contributor.authorFrancisco Morcillo, Javier
dc.date.accessioned2023-05-02T06:24:01Z
dc.date.available2023-05-02T06:24:01Z
dc.date.issued2023
dc.description.abstractIt has been shown that senescent cells accumulate in transient structures of the embryo that normally degenerate during tissue development. A collection of biomarkers is generally accepted to define senescence in embryonic tissues. The histochemical detection of β-galactosidase activity at pH 6.0 (β-galpH6) is the most widely used assay for cellular senescence. Immunohistochemical detection of common mediators of senescence which block cell cycle progression, including p16, p21, p63, p15 or p27, has also been used to characterize senescent cells in the embryo. However, the reliability of this techniques has been discussed in recent publications because nonsenescent cells are also labelled during development. Indeed, increased levels of senescent markers promote differentiation over apoptosis in developing neurons, suggesting that machinery used for the establishment of cellular senescence is also involved in neuronal maturation. Notably, it has recently been argued that a comparable state of cellular senescence might be adopted by terminally differentiated neurons. The developing sensory systems provide excellent models for studying if canonical markers of senescence are associated with terminal neuronal differentiation.es
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dc.format.extent10es
dc.identifier.citationHistology and Histopathology, Vol.38, nº5, (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-549
dc.identifier.urihttp://hdl.handle.net/10201/130504
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectβ-Galactosidasees
dc.subjectCell differentiationes
dc.subjectDevelopmental cell senescencees
dc.subjectHistochemistryes
dc.subjectOlfactory epitheliumes
dc.subjectSensory systemes
dc.subjectVertebrate embryoes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMarkers of senescence are often associated with neuronal differentiation in the developing sensory systemses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº5 (2023)