Publication:
Markers of senescence are often associated with neuronal differentiation in the developing sensory systems

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Mera-Rodriguez-38-493-502-2023.pdf(10.61 MB)
Date
2023
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Authors
Mera Rodríguez, José Antonio ; Álvarez Hernán, Guadalupe ; Gañán, Yolanda ; Solana Fajardo, Jorge ; Martín Partido, Gervasio ; Rodríguez León, Joaquín ; Francisco Morcillo, Javier
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-18-549
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info:eu-repo/semantics/article
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Abstract
It has been shown that senescent cells accumulate in transient structures of the embryo that normally degenerate during tissue development. A collection of biomarkers is generally accepted to define senescence in embryonic tissues. The histochemical detection of β-galactosidase activity at pH 6.0 (β-galpH6) is the most widely used assay for cellular senescence. Immunohistochemical detection of common mediators of senescence which block cell cycle progression, including p16, p21, p63, p15 or p27, has also been used to characterize senescent cells in the embryo. However, the reliability of this techniques has been discussed in recent publications because nonsenescent cells are also labelled during development. Indeed, increased levels of senescent markers promote differentiation over apoptosis in developing neurons, suggesting that machinery used for the establishment of cellular senescence is also involved in neuronal maturation. Notably, it has recently been argued that a comparable state of cellular senescence might be adopted by terminally differentiated neurons. The developing sensory systems provide excellent models for studying if canonical markers of senescence are associated with terminal neuronal differentiation.
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β-Galactosidase , Cell differentiation , Developmental cell senescence , Histochemistry , Olfactory epithelium , Sensory system , Vertebrate embryo
Citation
Histology and Histopathology, Vol.38, nº5, (2023)
URI
http://hdl.handle.net/10201/130504
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Histology and histopathology Vol.38, nº5 (2023)
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