Publication: Muller glia cells and their possible roles during retina differentiation in vivo and in vitro
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Date
1998
Authors
Willbold, E. ; Layer, P.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Muller cells are astrocyte-like radial glia
cells which are formed exclusively in the retina. Here we
present evidence that Muller cells are crucially involved
in the development of the retina's architecture and
circuitry. There is increasing evidence that Muller cells
are present from the very early beginning of retinogenesis.
We postulate the "gradual maturation hypothesis
of Muller cells". According to this hypothesis, Miiller
cells are continuously generated by a gradual transition
of neuroepithelial stem cells into mature Muller cells.
This process may be partly reversible. Muller cells, or
their immature precursors, are able to subserve different
functions. They are primary candidates for stabilizing
the complex retina1 architecture and for providing an
orientation scaffold. Thereby, they introduce a reference
system for the migration and correct allocation
of neurons. Moreover, they may provide spatial
information and microenvironmental cues for
differentiating neurons, and may also be important for
the segregation of cell and fibre layers. Additionally,
they seem to be involved in the guidance of axonal fibres
both in radial and in lateral directions, as they are
involved in the support and stabilization of synapses.
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