Publication: Metaplasia of the parietal layer of Bowman's capsule in the human kidney. Incidence in alcoholic liver disease and hypertension
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Date
1988
Authors
Haensly, William E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This report is the second of two surveys to
determine the incidence of metaplasia of Bowman's
parietal epithelium in the human kidney. Human kidney
sections obtained at autopsy at the Department of
Pathology, University of Texas Medical Branch,
Galveston, Texas, were examined with the light
microscope. The kidneys were fixed in neutral formalin,
sectioned at 6 pm and stained with hematoxylin and
eosin. Autopsy records were consulted after kidney
section examination to determine if there was any
correlation between clinical disease, histopathological
changes in organ systems and metaplasia of Bowman's
capsule. The kidney sections represented both sexes in 8
age groups, from less than one year to 80 years. A total
of 174 kidneys, representing 174 individuals, were
evaluated. One hundred renal corpuscles were counted
per section and the parietal layer of Bowman's capsule
was classified as normal (squamous) or metaplastic
(cuboidal). Of the 174 kidneys examined, 137 (79% )- 79
male and 58 female - had metaplasia of Bowman's
capsule. On the average, in the kidneys with the lesion,
6% of the renal corpuscles had metaplasia of Bowman's
parietal layer. The lesion was present in both sexes in all
age groups. The autopsy records revealed that
metaplasia of Bowman's parietal epithelium was usually
present with hepatic fatty changes andlor congestion.
Alcoholic liver disease and hypertension represented the most frequent clinical diseases in the sample; these
conditions had the highest incidence of metaplasia.
Twenty-six of the 174 kidney samples were from
individuals with alcoholic liver disease, all of whom had
metaplasia of Bowman's capsule. In the latter kidneys
the mean percentage of glomerular capsules with
metaplasia was 14%, with a range of l to 46%. Thirtyeight
of the 174 kidney samples were from individuals
with hypertension, 29 (76% ) of whom had metaplasia of Bowman's capsule. In these kidneys the mean
percentage of glomerular capsules with metaplasia was
6% with a range of 1 to 16%. These observations suggest
that metaplasia of Bowman's parietal epithelium is a
common occurrence in the human kidney under different
pathological conditions, and is especially prominent in
alcoholic liver disease and hypertension.
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