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The influence of immunosuppressants on the morphology, proliferating cell nuclear antigen (PCNA) and apoptosis in the rat ventral prostate

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dc.contributor.authorGrabowska, Marta
dc.contributor.authorSłuczanowska-Głąbowska, Sylwia
dc.contributor.authorKram, Andrzej
dc.contributor.authorTeresiński, Leszek
dc.contributor.authorPiasecka, Małgorzat
dc.contributor.authorPodhorska-Okołów, Marzenna
dc.contributor.authorRotter, Iwona
dc.contributor.authorKędzierska, Karolina
dc.contributor.authorSporniak-Tutak, Katarzyna
dc.contributor.authorCiechanowski, Kazimierz
dc.contributor.authorLaszczyńska, Maria
dc.date.accessioned2020-09-24T13:18:27Z
dc.date.available2020-09-24T13:18:27Z
dc.date.issued2015
dc.description.abstractAim: Analysis of the impact of immunosuppressants on apoptosis and PCNA in the rat ventral prostate. Method: The studies were performed on 48 male Wistar rats. The animals were divided into a control group and 7 experimental groups. For 6 months, the rats were administered drugs such as: rapamycin (Rapa), cyclosporin A (CsA), tacrolimus (Tac), mycophenolate mofetil (MMF) and glucocorticosteroids (GS). During section of the rats, prostate ventral lobes were obtained. Morphological evaluation (HE, PAS), TUNEL assay, PCNA expression analysis and quantitative image computer analysis were performed. Results: The highest percentage of apoptosis in epithelial cells was observed in groups which received two combinations of drugs: (V) CsA, MMF, GS and (VII) Tac, MMF, GS. A much lower percentage of apoptotic epithelial cells was found in the groups where the treatment schemes included rapamycin throughout the duration of the study. Interestingly, the conversion of the treatment to rapamycin caused a significant reduction of apoptosis in epithelial cells as well as in proliferation in both epithelial and stromal cells. Conclusions: On one hand, the obtained results may explain the anticancer activity of rapamycin in reducing the proliferation of epithelial cells, and on the other hand the adverse effect of rapamycin in the form of reduced regeneration of these cells. Taking into account the prostate in isolation from other organs/systems, the dosage scheme with Rapa, Tac and GS would appear to be the most favorable, due to the smallest morphological changes.es
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dc.identifier.citationHistology and histopathology, Vol. 30, nº 9 (2015)
dc.identifier.doihttps://doi.org/10.14570/HH-11-606
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96462
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRat prostatees
dc.subjectApoptosises
dc.subjectPCNAes
dc.subjectImmunosuppressantses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleThe influence of immunosuppressants on the morphology, proliferating cell nuclear antigen (PCNA) and apoptosis in the rat ventral prostatees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº9 (2015)