Publication: Distribution of interstitial cells of Cajal in Meriones unguiculatus and alterations in the development of incomplete intestinal obstruction
Authors
Bo, Wu ; Li, Liu ; Hengyu, Gao ; Haimei, Sun ; Hong, Xue ; Xiaoshuang, Li ; Guoquan, Zhang ; Deshan, Zhou
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The interstitial cells of Cajal (ICCs) act as
pacemaker cells that are involved in gastrointestinal (GI)
motility disorders, although the pathogenesis of these
disorders is still unclear. The GI tract of Mongolian
gerbils shares similar anatomical features with that of
humans, but no investigation of ICCs has been reported
in the GI tracts of this animal. In the present study, we
first observed the distribution and morphological
features of ICCs in the Mongolian gerbil GI tract. The
ICCs were mainly distributed within the smooth muscle
layers (ICC-IM), the myenteric plexus (ICC-MY), the
deep muscular plexus in the small intestine (ICC-DMP)
and the submucosal surface of the circular muscle layer
in the colon (ICC-SM). The density of the ICC-IM
gradually decreased from the stomach to the colon,
whereas the density of the ICC-MY gradually increased.
Second, we compared differences in the ICCs between
the control and obstructed intestines, and no significant
difference was observed in the number of ICCs after 7
days of obstruction. However, the numbers were reduced
by approximately day 14 of obstruction. The pattern of
immunoreactivity also partly differed from that of the
control group, i.e., a scattered and interrupted network of
ICCs was often observed. Western blotting revealed that
p-Kit and SCF were significantly reduced in the dilated
intestines by day 14. Our results indicate that the
Mongolian gerbil may be a good animal model for
studying changes in ICCs that may contribute to the
pathogenesis of GI motility disorders.
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Citation
Histology and Histopathology, vol. 28, nº 12 (2013)
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