A Systematic Review and Meta-Analysis of Serum Adiponectin Measurements in the Framework of Dog Obesity

Muñoz-Prieto, Alberto; Cerón, José Joaquín; Martínez-Subiela, Silvia; Mrljak, Vladimir; Tvarijonaviciute, Asta

Publication:
A Systematic Review and Meta-Analysis of Serum Adiponectin Measurements in the Framework of Dog Obesity

dc.contributor.author	Muñoz-Prieto, Alberto
dc.contributor.author	Cerón, José Joaquín
dc.contributor.author	Martínez-Subiela, Silvia
dc.contributor.author	Mrljak, Vladimir
dc.contributor.author	Tvarijonaviciute, Asta
dc.contributor.department	Medicina y Cirugía Animal
dc.date.accessioned	2024-02-10T18:13:57Z
dc.date.available	2024-02-10T18:13:57Z
dc.date.issued	2020-09-14
dc.description	©2020. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published, version of a Published Work that appeared in final form in Animals. To access the final edited and published work see https://doi.org/https://doi.org/10.3390/ani10091650	es
dc.description.abstract	Adiponectin is an abundant plasma protein that is closely related to obesity and obesity-related pathologies. The molecule can be found in three different isoforms, each with different biological activities. Studies on canine obesity have suggested that adiponectin concentrations are decreased in obesity; however, no canine meta-analyses have been performed that feature all the required data. The aim of this study is to perform a systematic review and meta-analysis of studies that pertain to total and high molecular weight (HMW) adiponectin in relation to canine obesity. From 20 different studies, a total of 366 dogs with obesity and 349 normal weight dogs are included in the meta-analysis. Client-owned dogs were most represented, accounting for 54.3% of the dogs used, while experimental dogs enrolled in the studies made up the remaining 45.7%. The concentrations of total adiponectin in dogs with obesity were significantly lower compared with normal weight dogs. Additionally, adiponectin concentrations were significantly higher in dogs after a successful weight loss protocol compared to the start of the protocol and were significantly lower in dogs after gaining weight. In conclusion, although caution should be taken due to the relatively low number of studies that exist and the high heterogeneity between them, this meta-analysis indicates that adiponectin is decreased in obese dogs.</p>	es
dc.format	application/pdf	es
dc.format.extent	15	es
dc.identifier.citation	Animals
dc.identifier.doi	https://doi.org/10.3390/ani10091650
dc.identifier.issn	2076-2615
dc.identifier.uri	http://hdl.handle.net/10201/139206
dc.language	eng	es
dc.relation	Sin financiación externa a la Universidad	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Adiponectin	es
dc.subject	Obesity	es
dc.subject	Serum	es
dc.subject	Dogs	es
dc.subject	Meta-analysis	es
dc.title	A Systematic Review and Meta-Analysis of Serum Adiponectin Measurements in the Framework of Dog Obesity	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es