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Advances in molecular classification of renal neoplasms

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dc.contributor.authorYin-Goen, Q.es
dc.contributor.authorDale, J.es
dc.contributor.authorYang, W.L.
dc.contributor.authorPhan, J.
dc.contributor.authorMoffitt, R.
dc.contributor.authorPetros, J.A.
dc.contributor.authorDatta, M.W.
dc.contributor.authorAmin, M.B.
dc.contributor.authorWang, M.D.
dc.contributor.authorYoung, A.N.
dc.date.accessioned2011-06-30T12:02:24Z
dc.date.available2011-06-30T12:02:24Z
dc.date.issued2006
dc.description.abstractKidney neoplasms are classified by light microscopy using the World Health Organization (WHO) system. The WHO system defines histopathologic tumor subtypes with distinct clinical behavior and underlying genetic mutations. In adults, the common malignant subtypes are variants of renal cell carcinoma (RCC). Histopathologic classification is critical for clinical management of RCC, but is becoming more complex with recognition of novel tumor subtypes, development of procedures yielding small diagnostic biopsies, and emergence of molecular therapies directed at tumor gene activity. Therefore, classification systems based on gene expression are likely to become essential for diagnosis, prognosis and treatment of kidney tumors. Recent DNA microarray studies have shown that clinically relevant renal tumor subtypes are characterized by distinct gene expression profiles, which are useful for discovery of novel diagnostic and prognostic biomarkers. In this review, we summarize the WHO classification system for renal tumors, general applications of microarray technology in cancer research, and specific microarray studies that have advanced knowledge of renal tumor diagnosis, prognosis, therapy and pathobiology.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22629
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectKidney Neoplasmses
dc.subjectMicroarrayes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.6 - Patología del sistema genitourinarioes
dc.titleAdvances in molecular classification of renal neoplasmses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.21, nº 3 (2006)