Publication: Advances in molecular classification of renal neoplasms
Authors
Yin-Goen, Q. ; Dale, J. ; Yang, W.L. ; Phan, J. ; Moffitt, R. ; Petros, J.A. ; Datta, M.W. ; Amin, M.B. ; Wang, M.D. ; Young, A.N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Kidney neoplasms are classified by light
microscopy using the World Health Organization
(WHO) system. The WHO system defines
histopathologic tumor subtypes with distinct clinical
behavior and underlying genetic mutations. In adults, the
common malignant subtypes are variants of renal cell
carcinoma (RCC). Histopathologic classification is
critical for clinical management of RCC, but is
becoming more complex with recognition of novel
tumor subtypes, development of procedures yielding
small diagnostic biopsies, and emergence of molecular
therapies directed at tumor gene activity. Therefore,
classification systems based on gene expression are
likely to become essential for diagnosis, prognosis and
treatment of kidney tumors. Recent DNA microarray
studies have shown that clinically relevant renal tumor
subtypes are characterized by distinct gene expression
profiles, which are useful for discovery of novel
diagnostic and prognostic biomarkers. In this review, we
summarize the WHO classification system for renal
tumors, general applications of microarray technology in
cancer research, and specific microarray studies that
have advanced knowledge of renal tumor diagnosis,
prognosis, therapy and pathobiology.
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