Publication: Histologic evaluation of the effect of grape seed oil and ferric sulfate in pulpotomy applied to molar teeth of rats: An in vivo study
Authors
Günay Yapici Yavuz ; Ebru Elibol Annaç ; Aydın Keskinrüzgar ; Muhammed Baybatmaz ; İlknur Öz ; Mesut Tozar ; Osman Küçükkelepçe ; Kamile Nur Tozar
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Publisher
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Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-25-008
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info:eu-repo/semantics/article
Description
Abstract
Background. The objective of this study was
to examine the healing potential of Grape Seed Oil
(GSO) on the pulp tissue that remains following
pulpotomy treatment.
Materials and Methods. The upper first molars of 18
two-month-old male Wistar albino rats were divided into
two groups according to the material used in pulpotomy
treatment. In the pulpotomy treatment group, GSO was
used, while ferric sulfate (FS) was used in the control
group. The rats were euthanized at 24 hours, 15 days,
and 30 days following treatment. Histopathological
evaluation of the samples was conducted using the
hematoxylin-eosin staining method. The evaluation was
conducted to ascertain alterations in connective tissue,
vascular changes (i.e., angiopathic findings),
inflammation, and hemorrhagic findings in the pulp. The
data obtained in this study were analyzed with the IBM
SPSS Statistics Version 21 software program.
Results. In the present study, it was observed that the
inflammatory response in the GSO group was higher
than that in the FS group at 24 hours. The investigation
revealed that the vascular response exhibited a higher
magnitude in the GSO group compared to the FS group
at 24 hours and at day 15. However, this response
exhibited a decline at day 30. Despite an increase in
hemorrhaging on the 15th day in the GSO group, this
phenomenon decreased over time.
Conclusions. It has been observed that GSO is a
biocompatible material that can be used as an alternative
to FS in pulpotomy treatment.
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