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Tumor promotion or suppression: Revisiting the role of EXT1 and heparan sulfate

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dc.contributor.authorHiroyuki Tomita
dc.contributor.authorAkira Hara
dc.contributor.authorAyumi Niwa
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biología Celular e Histología
dc.date.accessioned2026-03-23T09:34:19Z
dc.date.available2026-03-23T09:34:19Z
dc.date.issued2026
dc.description.abstractHeparan sulfate (HS), a linear sulfated polysaccharide attached to proteoglycans, modulates the availability and activity of growth factors and cytokines to regulate cell signaling, adhesion, and migration. Exostosin-1 (EXT1), a key glycosyl-transferase for HS chain elongation, is increasingly implicated in cancer development and progression. Although originally identified as a tumor suppressor in hereditary multiple exostoses, EXT1 exhibits a complex, context-dependent role in cancer. The effects of EXT1 in cancer differ by cell and tumor type, exerting both tumor-suppressing and tumor-promoting effects. Notably, EXT1 also alters the tumor microenvironment via its expression in stromal fibroblasts and endothelial cells, further influencing tumor behavior. This review discusses the functions of HS and EXT1, emphasizing the roles of EXT1 in cancer and its microenvironment. A deeper understanding of these mechanisms may offer novel therapies targeting the HS biosynthetic pathway.
dc.formatapplication/pdf
dc.format.extent9
dc.identifier.doihttps://doi.org/10.14670/HH-18-985
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/221921
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHeparan sulfate
dc.subjectCancer
dc.subjectEXT1
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleTumor promotion or suppression: Revisiting the role of EXT1 and heparan sulfate
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº4, (2026)