Chromosome instability and kinetochore dysfunction

Publication:
Chromosome instability and kinetochore dysfunction

dc.contributor.author	Tomonaga, T.	es
dc.contributor.author	Nomura, F.	es
dc.date.accessioned	2012-05-21T12:08:45Z
dc.date.available	2012-05-21T12:08:45Z
dc.date.issued	2007
dc.description.abstract	Chromosomal instability (CIN) has been recognized as a hallmark of human cancer and is caused by continuous chromosome missegregation during mitosis. Proper chromosome segregation requires a physical connection between spindle microtubules and centromeric DNA and this attachment occurs at proteinaceous structures called kinetochore. Thus, defect in kinetochore function is a candidate source for CIN and the generation of aneuploidy. Recently, a number of kinetochore components have been shown to be mutated and/or aberrantly expressed in human cancers, which suggests an important role of kinetochore for CIN and carcinogenesis. In this article, we will discuss about how kinetochore dysfunction causes CIN and might lead to the development of cancer.	es
dc.format	application/pdf	es
dc.format.extent	7	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/27548
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Kinetochore	es
dc.subject	Cancer	es
dc.subject.other	61 - Medicina	es
dc.title	Chromosome instability and kinetochore dysfunction	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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