Publication: Chromosome instability and kinetochore dysfunction
Authors
Tomonaga, T. ; Nomura, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Chromosomal instability (CIN) has been
recognized as a hallmark of human cancer and is caused
by continuous chromosome missegregation during
mitosis. Proper chromosome segregation requires a
physical connection between spindle microtubules and
centromeric DNA and this attachment occurs at
proteinaceous structures called kinetochore. Thus, defect
in kinetochore function is a candidate source for CIN
and the generation of aneuploidy. Recently, a number of
kinetochore components have been shown to be mutated
and/or aberrantly expressed in human cancers, which
suggests an important role of kinetochore for CIN and
carcinogenesis. In this article, we will discuss about how
kinetochore dysfunction causes CIN and might lead to
the development of cancer.
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Citation
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