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Pathological changes in organs of rats chronically exposed to hypoxia. Development of pulmonary lipidosis

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dc.contributor.authorWolman, M.
dc.contributor.authorCervós-Navarro, J.
dc.contributor.authorSampaolo, S.
dc.contributor.authorCardesa, Antonio
dc.date.accessioned2017-06-06T12:49:37Z
dc.date.available2017-06-06T12:49:37Z
dc.date.issued1993
dc.description.abstractRats were exposed to chronic normobaric hypoxia of progressively increasing severity; down to 8% or 7% oxygen concentrations. In addition to loss of weight, pathology revealed congestion, haemorrhages, hypertrophy of the heart involving mainly the right ventricle, thickening of arteries, ischaemic changes in the myocardium and extrarnedullary haematopoiesis in the spleen. Changes not described up until now were: 1) sheets of foam cells in the pulmonary alveoli; 2) foamy and solid storing cells in the spleen; 3) mucoid changes in the atrioventricular valve leaflets; 4) hyperplasia of the juxtaglomerular apparatus; 5) atrophy of the adrenal glomerulosa and hyperplasia of medulla; 6) atrophy of the perifollicular B-cell zone in the spleen; and 7) lipid pigment deposition in various organs. The findings indicate that severe chronic hypoxia induces a significant pulmonary lipidosis similar to that caused by amphiphilic cationic drugs, presumably by inhibiting hydrolytic enzyme activities. The observations are of importante in human hypoxic conditions and open the possibility of their rational treatment.
dc.formatapplication/pdfes
dc.format.extent9
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/53198
dc.languageenges
dc.publisherMurcia : F. Hernández
dc.relation.ispartofHistology and histopathology
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectChronic hypoxia
dc.subjectPathology
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
dc.titlePathological changes in organs of rats chronically exposed to hypoxia. Development of pulmonary lipidosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 8, nº 2 (1993)