Publication: Pathological changes in organs of rats chronically exposed to hypoxia. Development of pulmonary lipidosis
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Date
1993
Authors
Wolman, M. ; Cervós-Navarro, J. ; Sampaolo, S. ; Cardesa, Antonio
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Rats were exposed to chronic normobaric
hypoxia of progressively increasing severity; down to
8% or 7% oxygen concentrations. In addition to loss of
weight, pathology revealed congestion, haemorrhages,
hypertrophy of the heart involving mainly the right
ventricle, thickening of arteries, ischaemic changes in
the myocardium and extrarnedullary haematopoiesis in
the spleen. Changes not described up until now were:
1) sheets of foam cells in the pulmonary alveoli; 2)
foamy and solid storing cells in the spleen; 3) mucoid
changes in the atrioventricular valve leaflets; 4)
hyperplasia of the juxtaglomerular apparatus; 5) atrophy
of the adrenal glomerulosa and hyperplasia of medulla;
6) atrophy of the perifollicular B-cell zone in the spleen;
and 7) lipid pigment deposition in various organs. The
findings indicate that severe chronic hypoxia induces a
significant pulmonary lipidosis similar to that caused by
amphiphilic cationic drugs, presumably by inhibiting
hydrolytic enzyme activities. The observations are of
importante in human hypoxic conditions and open the
possibility of their rational treatment.
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