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Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands

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dc.contributor.authorMalendowicz, L.K.es
dc.contributor.authorJedrzejczak, N.es
dc.contributor.authorBelloni, A. S.
dc.contributor.authorTretjer, M.
dc.contributor.authorHochol, A.
dc.contributor.authorNussdorfer, G.G.
dc.date.accessioned2011-05-11T10:56:36Z
dc.date.available2011-05-11T10:56:36Z
dc.date.issued2001
dc.description.abstractOrexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OXIR and OX2R. OXIR is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmollkg body weight of orexins on the secretion and proliferative activity of immature (20-day-old) and regenerating rat adrenal cortex. The presence of both OXIR and OX2R mRNAs has been detected by reverse transcriptionpolymerase chain reaction in adult, immature and regenerating adrenals. Orexin-A increased corticosterone plasma concentration in immature rats, but not in animals with regenerating adrenals. Both orexins raised metaphase index (%o of metaphase-arrested cells) in immature rat adrenals, orexin-B being more effective than orexin-A. In contrast, both orexins equipotently lowered adrenal metaphase index at day 5 (but not day 8) of adrenal regeneration. We conclude that orexins (1) stimulate secretion and proliferative activity of immature rat adrenals, acting through OXIR and OX2R, respectively; and (2) do not affect secretion, but inhibit proliferative activity of regenerating adrenals, mainly via the activation of OX2R.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20694
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOrexinses
dc.subjectOrexin receptorses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleEffects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glandses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.16, nº 3 (2001)