Publication: Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands
Loading...
Date
2001
Authors
Malendowicz, L.K. ; Jedrzejczak, N. ; Belloni, A. S. ; Tretjer, M. ; Hochol, A. ; Nussdorfer, G.G.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Orexins A and B are two hypothalamic
peptides, involved in the central regulation of feeding,
which act through two receptor subtypes, named OXIR
and OX2R. OXIR is selective for orexin-A, and OX2R
binds both orexins. We have investigated the effects of
three subcutaneous injections of 10 nmollkg body
weight of orexins on the secretion and proliferative
activity of immature (20-day-old) and regenerating rat
adrenal cortex. The presence of both OXIR and OX2R
mRNAs has been detected by reverse transcriptionpolymerase
chain reaction in adult, immature and
regenerating adrenals. Orexin-A increased corticosterone
plasma concentration in immature rats, but not in
animals with regenerating adrenals. Both orexins raised
metaphase index (%o of metaphase-arrested cells) in
immature rat adrenals, orexin-B being more effective
than orexin-A. In contrast, both orexins equipotently
lowered adrenal metaphase index at day 5 (but not day
8) of adrenal regeneration. We conclude that orexins (1)
stimulate secretion and proliferative activity of immature
rat adrenals, acting through OXIR and OX2R,
respectively; and (2) do not affect secretion, but inhibit
proliferative activity of regenerating adrenals, mainly via
the activation of OX2R.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.