Publication: Pax genes in development and maturation of the vertebrate visual system: Implications for optic nerve regeneration
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Date
2001
Authors
Ziman, M.R. ; Rodger, J. ; Chen, P. ; Papadimitriou, J.M. ; Dunlop, S.A. ; Beazley, L.D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Pax genes play a pivotal role in development
of the vertebrate visual system. Paxó is the master
control gene for eye development: ectopic expression of
Paxó in Xenopus laevis and Drosphila melanogaster
leads to the formation of differentiated eyes on the legs
or wings. Paxó is involved in formation of ganglion cells
of the retina, as well as cells of the lens, iris and cornea.
In addition Pax6 may play a role in axon guidance in the
visual system.
Pax2 regulates differentiation of the optic disk
through which retinal ganglion cell axons exit the eye.
Furthermore, Pax2 plays a critical role in development of
the optic chiasm and in the guidance of axons along the
contralateral or ipsilateral tracts of the optic nerve to
visual targets in the brain.
During development Pax7 is expressed in neurona1
cells of one of the major visual targets in the brain, the
optic tectumlsuperior colliculus. Neurons expressing
Pax7 migrate towards the pia and concentrate in the
stratum griseum superficiale (SGFS), the target site for
retinal axons. Together, expression of Pax2, 6 and 7 may
guide axons during formation of functional retinotectal/
collicular projections.
Highly regulated Pax gene expression is also
observed in mature animals. Moreover, evidence
suggests that Pax genes are important for regeneration of
the visual system. We are currently investigating Pax
gene expression in species that display a range of
outcomes of optic nerve regeneration. We predict that
such information will provide valuable insights for the
induction of successful regeneration of the optic nerve and of other regions of the central nervous system in
mammals including man.
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