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Influence of preformed antibodies in liver transplantation

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dc.contributor.authorBoix, Francisco
dc.contributor.authorLópez, Manuela
dc.contributor.authorAlfaro, Rafael
dc.contributor.authorGalián, José A.
dc.contributor.authorLlorente, Santiago
dc.contributor.authorCampillo, José A.
dc.contributor.authorBotella, Carmen
dc.contributor.authorRamírez, Pablo
dc.contributor.authorSánchez Bueno, Francisco
dc.contributor.authorPons, José A.
dc.contributor.authorMoya Quiles, María R.
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorMuro, Manuel
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T07:44:51Z
dc.date.available2024-07-12T07:44:51Z
dc.date.issued2020-03-05
dc.description© 2020 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in Journal of Clinical Medicine. To access the final edited and published work see https://doi.org/10.3390/jcm9030708
dc.description.abstractThe significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to analyze the presence of DSAs in a large cohort of 810 liver recipients undergoing liver transplant to determine the influence on acute (AR) or chronic liver rejection (CR), graft loss and allograft survival. DSAs were identified using complement dependent cytotoxicity crossmatch (CDC-CM) and multiplexed solid-phase-based flow cytometry assay (Luminex). CDC-CM showed that a 3.2% of liver transplants were positive (+CDC-CM) with an AR frequency of 19.2% which was not different from that observed in negative patients (−CDC-CM, 22.3%). Only two patients transplanted with +CDC-CM (7.6%) developed CR and suffered re-transplant. +CDC-CM patients showed a significantly lower survival rate compared to −CDC-CM patients (23.1% vs. 59.1%, p = 0.0003), developing allograft failure within the first three months (p < 0.00001). In conclusion, we have demonstrated a relationship between the presence of preformed DSAs and the low graft liver survival, indicating the important role and the potential interest of performing this analysis before liver transplantation. Our results could help to detect patients with an increased risk of graft loss, a better choice of liver receptors as well as the establishment of individualized immunosuppressive regimens.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationJournal of Clinical Medicine, 2020, Vol. 9 (3): 708
dc.identifier.doihttps://doi.org/10.3390/jcm9030708
dc.identifier.issnElectronic: 2077-0383
dc.identifier.urihttp://hdl.handle.net/10201/143039
dc.languageenges
dc.publisherMDPI
dc.relationThis work was possible thank to support from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness. Grant Number PI11/02686, PI15/01370 and PI19/01194co-funding of the European Union with European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe”.es
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/9/3/708
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAlcoholic cirrhosises
dc.subjectCrossmatches
dc.subjectCauses of deathes
dc.subjectDonor specific antibodieses
dc.subjectLiver rejectiones
dc.subjectForensic medicinees
dc.subjectMedico legal autopsyes
dc.subjectSurvivales
dc.titleInfluence of preformed antibodies in liver transplantationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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