Publication: Influence of preformed antibodies in liver transplantation
Authors
Boix, Francisco ; López, Manuela ; Alfaro, Rafael ; Galián, José A. ; Llorente, Santiago ; Campillo, José A. ; Botella, Carmen ; Ramírez, Pablo ; Sánchez Bueno, Francisco ; Pons, José A. ; Moya Quiles, María R. ; Minguela, Alfredo ; Muro, Manuel ; Legaz Pérez, Isabel
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Publisher
MDPI
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DOI
https://doi.org/10.3390/jcm9030708
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info:eu-repo/semantics/article
Description
© 2020 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published version of a Published Work that appeared in final form in Journal of Clinical Medicine. To access the final edited and published work see https://doi.org/10.3390/jcm9030708
Abstract
The significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to analyze the presence of DSAs in a large cohort of 810 liver recipients undergoing liver transplant to determine the influence on acute (AR) or chronic liver rejection (CR), graft loss and allograft survival. DSAs were identified using complement dependent cytotoxicity crossmatch (CDC-CM) and multiplexed solid-phase-based flow cytometry assay (Luminex). CDC-CM showed that a 3.2% of liver transplants were positive (+CDC-CM) with an AR frequency of 19.2% which was not different from that observed in negative patients (−CDC-CM, 22.3%). Only two patients transplanted with +CDC-CM (7.6%) developed CR and suffered re-transplant. +CDC-CM patients showed a significantly lower survival rate compared to −CDC-CM patients (23.1% vs. 59.1%, p = 0.0003), developing allograft failure within the first three months (p < 0.00001). In conclusion, we have demonstrated a relationship between the presence of preformed DSAs and the low graft liver survival, indicating the important role and the potential interest of performing this analysis before liver transplantation. Our results could help to detect patients with an increased risk of graft loss, a better choice of liver receptors as well as the establishment of individualized immunosuppressive regimens.
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Citation
Journal of Clinical Medicine, 2020, Vol. 9 (3): 708
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/