Validation of multi-residue method for quantification of antibiotics and nsaids in avian scavengers by using small amounts of plasma in HPLC-MS-TOF.

Blanco, Guillermo; García Fernández, Antonio Juan; Gómez Ramírez, Pilar

Publication:
Validation of multi-residue method for quantification of antibiotics and nsaids in avian scavengers by using small amounts of plasma in HPLC-MS-TOF.

dc.contributor.author	Blanco, Guillermo
dc.contributor.author	García Fernández, Antonio Juan
dc.contributor.author	Gómez Ramírez, Pilar
dc.contributor.department	Ciencias Sociosanitarias
dc.date.accessioned	2025-01-30T16:53:53Z
dc.date.available	2025-01-30T16:53:53Z
dc.date.issued	2020-06-06
dc.description	© 2020 Authors. This document is the published version of a published work that appeared in final form in International Journal of Environmental Research and Public Health. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 . To access the final edited and published work see: https://doi.org/10.3390/ijerph17114058
dc.description.abstract	Pharmaceuticals are still considered emerging pollutants a ecting both aquatic and terrestrial ecosystems. Scavenging bird species may be exposed to veterinary drugs when they feed on livestock carcasses provided at supplementary feeding stations, as these are often stocked with ailing and/or recently medicated animals. Because those animals may be a source of several di erent pharmaceutical compounds, analytical methods to evaluate residue levels and exposure potential should enable detection and quantification of asmanydi erent compounds as possible, preferably from small sample volumes. Four di erent extraction methods were tested to conduct HPLC-MS-TOF analysis of some of the most common veterinary drugs used in livestock in Spain. The method deemed most viable was a simple extraction, using methanol and 100 L of plasma, that allowed quantification of seven antibiotics (tetracycline, oxytetracycline, ciprofloxacin, enrofloxacin, nalidixic acid, trimethoprim, sulfadiazine) and five nonsteroidal anti-inflammatory drugs (NSAIDs) (meloxicam, flunixin, carprofen, tolfenamic acid, phenylbutazone). The method was then applied to analysis of 29 Eurasian gri on vulture (Gyps fulvus) nestling samples, wherein enrofloxacin and tolfenamic acid were most commonly detected (69% and 20%, respectively). To our knowledge, this is the first study including NSAIDs in the exposure assessment of di erent classes of veterinary pharmaceuticals in live avian scavengers.
dc.format	application/pdf	es
dc.format.extent	13
dc.identifier.citation	Int. J. Environ. Res. Public Health 2020, 17(11), 405
dc.identifier.doi	https://doi.org/10.3390/ijerph17114058
dc.identifier.issn	Print.: 1661-7827
dc.identifier.issn	Electronic.: 1660-4601
dc.identifier.uri	http://hdl.handle.net/10201/149771
dc.language	eng	es
dc.publisher	MDPI
dc.relation	CGL2010-15726 del Ministerio of Economía y Competitividad.y 20945/PI/18 de la Fundación Séneca - Agencia de Ciencia y Tecnología de la Región de Murcia.	es
dc.relation.publisherversion	https://www.mdpi.com/1660-4601/17/11/4058
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Veterinary pharmaceuticals
dc.subject	Risk assessment
dc.subject	Analysis
dc.subject	Vultures
dc.subject	Drug mixtures
dc.title	Validation of multi-residue method for quantification of antibiotics and nsaids in avian scavengers by using small amounts of plasma in HPLC-MS-TOF.	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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