Publication: Ultrastructural study of the neuroglial and macrophagic reaction in Wallerian degeneration of the adult rat optic nerve
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Date
1991
Authors
Carbonell, A.L. ; Boya, J. ; Calvo, J.L. ; Marín, J.F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Wallerian degeneration of the optic
nerve of adult rat has been studied after destroying the
retina. Animals were sacrificed between 4 days and 1
year after the lesion. Different cell types of the optic
nerve have been studied ultrastructurally. Our results
demonstrate the existence of a population of
macrophages, probably of microglial origin, responsible
for scavenging degenerated myelin. Astrocytes suffer a
process of proliferation and hypertrophy. and are
massively stuffed by gliofilaments, leading to a glial scar.
These cells apparently do not participate in phagocytic
phenomena, while some cytoplasmic inclusions (e.g.
lipid droplets) suggest some implication in the local
metabolization of some tissue degradation products.
Oligodendrocytes do not undergo ultrastructural
changes, showing a rather quiescent appearance.
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