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Expression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expression

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dc.contributor.authorLee, Li-Yues
dc.contributor.authorWu, Chi-Minges
dc.contributor.authorWang, Chee-Chan
dc.contributor.authorYu, Jau-Song
dc.contributor.authorLiang, Ying
dc.contributor.authorHuang, Kuo-Hao
dc.contributor.authorLo, Chih-Hong
dc.contributor.authorHwang, Tsann-Long
dc.date.accessioned2013-01-22T10:01:12Z
dc.date.available2013-01-22T10:01:12Z
dc.date.issued2008
dc.description.abstractMatrix metalloproteinases (MMPs) MMP-2 and MMP-9 can degrade type IV collagen of extracellular matrix and basal membranes. Claudin-4 is a member of a large family of transmembrane proteins, claudins, essential in the formation and maintenance of tight junctions. Claudin-4 has been shown to activate MMP-2, indicating that claudin-mediated increased cancer cell invasion might be mediated through the activation of MMP proteins. To explore the roles of MMP-2, MMP-9 and claudin-4 in gastric cancer, we selected 88 cases and then analyzed the expression of these proteins using immunohistochemistry. We found that all of MMP-2, MMP-9 and claudin-4 expressions were significantly higher in intestinal-type than in diffuse-type gastric cancer. On further analysis, testing the relationship between MMP-2 and MMP-9 expression with claudin-4 expression, claudin-4 expression was significantly associated with MMP-9 expression, but not with MMP-2 expression. The results showed that MMP- 2, MMP-9 and claudin-4 expression may be phenotypic features, distinguishing intestinal-type and diffuse-type gastric cancer. Possibly, claudin-4 played a role in determining MMP-9 activity which favored intestinaltype gastric cancer to distal metastasis.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29808
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectClaudines
dc.subjectGastric canceres
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23, nº5 (2008)