Publication: Expression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expression
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Date
2008
Authors
Lee, Li-Yu ; Wu, Chi-Ming ; Wang, Chee-Chan ; Yu, Jau-Song ; Liang, Ying ; Huang, Kuo-Hao ; Lo, Chih-Hong ; Hwang, Tsann-Long
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Matrix metalloproteinases (MMPs) MMP-2
and MMP-9 can degrade type IV collagen of
extracellular matrix and basal membranes. Claudin-4 is a
member of a large family of transmembrane proteins,
claudins, essential in the formation and maintenance of
tight junctions. Claudin-4 has been shown to activate
MMP-2, indicating that claudin-mediated increased
cancer cell invasion might be mediated through the
activation of MMP proteins. To explore the roles of
MMP-2, MMP-9 and claudin-4 in gastric cancer, we
selected 88 cases and then analyzed the expression of
these proteins using immunohistochemistry. We found
that all of MMP-2, MMP-9 and claudin-4 expressions
were significantly higher in intestinal-type than in
diffuse-type gastric cancer. On further analysis, testing
the relationship between MMP-2 and MMP-9 expression
with claudin-4 expression, claudin-4 expression was
significantly associated with MMP-9 expression, but not
with MMP-2 expression. The results showed that MMP-
2, MMP-9 and claudin-4 expression may be phenotypic
features, distinguishing intestinal-type and diffuse-type
gastric cancer. Possibly, claudin-4 played a role in
determining MMP-9 activity which favored intestinaltype
gastric cancer to distal metastasis.
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