Publication: Ultrastructure of atheromatous lesions experimentally induced in Syrian hamsters of the APA strain
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Date
1997
Authors
Yamanouchi, J. ; Sugawara, Y. ; Itagaki, S. ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In order to examine whether diabetes
enhances primary aortic lesions up to atherosclerotic
ones, mild primary lesions were induced in aorta of APA
hamsters by an administration of vitamin D2 (VD)
andlor stop-and-reflow (SR)-operation, a modification of
renal artery clamping. At 2 months after the treatment
with the combination of VD-administration and SRoperation,
atheromatous lesions, characterized by an
appearance of many foam cells in the intima, were
observed in the abdominal aorta, the site of SRoperation,
in streptozotocin (SZ)-induced diabetic APA
hamsters. Foam cells in the atheromatous lesions were
originated from smooth muscle cells and monocytel
macrophages. On the other hand, neither VDadministration
alone nor SR-operation done developed
atheromatous lesions in SZ-induced diabetic APA
hamsters. In conclusion, we succeeded in a rapid
induction of atherosclerotic lesions in abdominal aorta of
SZ-induced diabetic APA hamsters by the combination
of VD-administration and SR-operation.
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