Publication: Formalin-induced experimental sclerosing
cholangitis in the rat
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Date
1989
Authors
Kotzampassi, K. ; Eleftheriadis, E. ; Tzioufa, V. ; Alvanou, A. ; Dadoukis, J. ; Foroglou, Ch. ; Aletras, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The few reported cases of sclerosing
cholangitis following removal of an echinococcus cyst are
thought to be a consequence of the chemical action of
formalin used for sterilization of the residual cavity. The
aim of this study was to assess this hypothesis.
We injected 0.15ml of 2% buffered formalin solution
into the central hepatic lobe of five rats, after a midline
laparotomy. At 6, 12, 18 and 24 weeks after formalin
injection al1 rats were reoperated upon and a sample of
hepatic parenchyma from both the central and the left
hepatic lobe was obtained for microscopic evaluation.
Our findings, dilatation of portal tracts and bile
canaliculi, thickening of the pericanalicular cytoplasm,
portal and periportal inflammatory cell infiltration and
fibrosis and enlargement of the perisinusoidal space of
Disse, suggest that 2% formalin solution leads to the
development of essential phenomena of cholestasis and
sclerosing cholangitis in the rat, so thus it should be
avoided in liver hydatid disease surgery.
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