Publication:
Role of insulin signaling and its associated signaling in glomerulus for diabetic kidney disease

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dc.contributor.authorMima, Akira
dc.contributor.authorYasuzawa, Toshinori
dc.date.accessioned2023-05-02T06:02:29Z
dc.date.available2023-05-02T06:02:29Z
dc.date.issued2023
dc.description.abstractThe number of patients with diabetic kidney disease (DKD) has been rising significantly over the last several decades and is one of the most frequent causes of chronic kidney disease (CKD) in the United States. Hyperglycemia accelerates development of DKD, a direct result of increased intracellular glucose availability. Two large clinical studies, the Diabetes Control and Complications Trial in type 1 diabetes and the United Kingdom Prospective Diabetes Study in type 2 diabetes showed that intensive glycemic control delayed the onset and the progression of DKD. On the other hand, it is reported that glycemic control alone is not sufficient to control DKD progression. Recent data support that insulin signaling and its associated signaling contribute significantly to preserve glomerular function. However, little is known about the key regulators of insulin signaling in glomerular component cells. In this review, we summarize the novel knowledge regarding the reno-protective effects of insulin signaling or its associated signaling in glomerular constituent cells on DKD.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.citationHistology and Histopathology, Vol.38, nÂş5, (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-543
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/130503
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDiabetic kidney disease (DKD)es
dc.subjectInsulin signalinges
dc.subjectInsulin receptor substrate 1 (IRS1)es
dc.subjectVascular endothelial growth factor (VEGF)es
dc.subjectPyruvate kinase M2 (PKM2)es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleRole of insulin signaling and its associated signaling in glomerulus for diabetic kidney diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nÂş5 (2023)