Publication: Role of insulin signaling and its associated signaling in glomerulus for diabetic kidney disease
Authors
Mima, Akira ; Yasuzawa, Toshinori
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-543
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The number of patients with diabetic kidney
disease (DKD) has been rising significantly over the last
several decades and is one of the most frequent causes of
chronic kidney disease (CKD) in the United States.
Hyperglycemia accelerates development of DKD, a
direct result of increased intracellular glucose
availability. Two large clinical studies, the Diabetes
Control and Complications Trial in type 1 diabetes and
the United Kingdom Prospective Diabetes Study in type
2 diabetes showed that intensive glycemic control
delayed the onset and the progression of DKD. On the
other hand, it is reported that glycemic control alone is
not sufficient to control DKD progression.
Recent data support that insulin signaling and its
associated signaling contribute significantly to preserve
glomerular function. However, little is known about the
key regulators of insulin signaling in glomerular
component cells. In this review, we summarize the novel
knowledge regarding the reno-protective effects of
insulin signaling or its associated signaling in glomerular
constituent cells on DKD.
publication.page.subject
Citation
Histology and Histopathology, Vol.38, nÂş5, (2023)
item.page.embargo
Ir a EstadĂsticas
Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/